英語翻譯在過去的十幾年裡,隨著人們對腫瘤發病機理的深入了解,一些在腫瘤發生過程中起重要作用的信號分子隨之被發現,並且已經

題目：

英語翻譯
在過去的十幾年裡,隨著人們對腫瘤發病機理的深入了解,一些在腫瘤發生過程中起重要作用的信號分子隨之被發現,並且已經成爲藥物作用的新靶點.在這些靶點當中,酪氨酸激酶成爲研究的熱點.目前大多數的EGFR抑制劑屬於ATP競爭性抑制劑,其部分結構片斷具有與ATP中腺嘌呤相似的結構特點.基於此特點並結合文獻報導的EGFR抑制劑的結構特徵,本論文以嘌呤類似物喹唑啉爲母核,分別在其4位和7位引入結構多樣的取代苯氨基和柔性側鏈,設計了一系列4-取代苯胺-6-(2-羥基取代丙氧基)-喹唑啉類化合物.以香草酸爲起始原料,經過酯化、硝化、還原、環合、氯代、取代、醚化等反應,合成了兩個未見文獻報導的目標化合物.化合物的結構經1H NMR和MS確證.

解答：

In the past decade,the deepened comprehension of the tumor pathogenesis has lead to the discovery of the 「signaling molecules」 which play important roles in the tumor occurrence.These 「signaling molecules」 have become new pharmaceutical targets among which the tyrosine kinase attracts significant research interest.Currently,many of the EGFR inhibitors,which comprise structural fragments similar to the adenine group of ATP,are in the category of ATP competitive inhibitors.Based on the abovementioned structural characteristic and with a reference to the molecule structures of many EGFR inhibitors previous reported,this article describes the design of a series of 4-substituted anilino -6-(2-hydroxypropyloxy)-quinazoline derivatives,which consist of a quinazoline (the purine analog) nucleus with various substituted anilino groups and flexible side-chains on its 4- and 7- position.In this article,two previously unreported compounds were synthesized from vanillic acid through the esterization,nitration,reduction,cyclization,chloro-substitution,substitution and etherization reactions.The structure of the compounds were characterized by 1H NMR and MS.
樓主,關鍵詞很多,要仔細核對參考文獻啊.